Worn out and fatigued canine?
DOG -TIRED

Maybe a canine is now missing ?
I’ll be DOGGONE

Doctor’s innovative clinic ?
“PRACTICE” makes perfect

Would be cross medical professional ?
might  NURSE a grievance

Chemical metal has a way of resolving things ?

They IRON things out !

Someone extremely skilled at being dull?

A “DRAB” DAB HAND
at it

PURR-sonal loveable  pet can be a “CAT”-ALYST
catalyst for charm!

This figure might hail from Italy ?

A ROMAN NUMERAL!

Efficient fire lighter to less efficient another ?

You are no MATCH!

The less efficient fire lighter may never CATCH FIRE

Familiar dwelling elsewhere ?
A HOME AWAY FROM HOME

Friendly home to another?
HOUSE it going